Latest Updates

Overview of Substance Use Disorders

    • Discussion of the evolution of DSM substance use disorder diagnoses over time
    • Overview of the biological, environmental, and personal factors implicated in the development of substance use disorders
    • Critical reviews of the current diagnostic criteria, epidemiology, and clinical presentation of the major substances of misuse

Overview of Substance Use Disorders

    • Discussion of the evolution of DSM substance use disorder diagnoses over time
    • Overview of the biological, environmental, and personal factors implicated in the development of substance use disorders
    • Critical reviews of the current diagnostic criteria, epidemiology, and clinical presentation of the major substances of misuse

Medical Management of Premature Ejaculation

    • The International Society for Sexual Medicine agreed on a definition of premature ejaculation in 2014.
    • Premature ejaculation (PE) classification has been expanded to include natural variable (variable PE) and premature-like ejaculatory dysfunction (subjective PE).
    • There is now well-established pharmacotherapy mainly with SSRIs with differing levels of efficacy as well as potential adjunctive therapy with topical or local anesthetics.

Diseases of the Pericardium, Cardiac Tumors, and Cardiac Trauma

    • Lightning strikes may also cause myocardial injury,
    • which may be evident through ECG changes, biomarker elevations, and echocardiographic ventricular wall motion abnormalities.
    • Pericarditis and pericardial effusion may also occur. These abnormalities tend to resolve within several weeks.

Diseases of the Pericardium, Cardiac Tumors, and Cardiac Trauma

    • Lightning strikes may also cause myocardial injury,
    • which may be evident through ECG changes, biomarker elevations, and echocardiographic ventricular wall motion abnormalities.
    • Pericarditis and pericardial effusion may also occur. These abnormalities tend to resolve within several weeks.

Intrahepatic Cholangiocarcinoma

    • The majority of patients with iCCA present with locally advanced or metastatic disease.
    • Surgery for patients iCCA involves margin-negative resection with porta hepatis lymphadenectomy including at least six lymph nodes.
    • Formal volumetry should be considered for patients requiring extended hepatectomy to ensure adequatefuture liver remnant size
    • Adjuvant chemotherapy should be considered after resection, particularly for high-risk features such as lymph node involvement or positive margins.

Intrahepatic Cholangiocarcinoma

    • The majority of patients with iCCA present with locally advanced or metastatic disease.
    • Surgery for patients iCCA involves margin-negative resection with porta hepatis lymphadenectomy including at least six lymph nodes.
    • Formal volumetry should be considered for patients requiring extended hepatectomy to ensure adequatefuture liver remnant size
    • Adjuvant chemotherapy should be considered after resection, particularly for high-risk features such as lymph node involvement or positive margins.

Sepsis

    • Sepsis syndromes have been redefined (Sepsis-3 definitions) by international experts, based on sepsis mortality data extracted large administrative databases.
    • National focus has turned to early identification of sepsis as a key determinant of outcomes. International critical care experts have recommended using the qSOFA criteria in the Emergency Department setting to identify sepsis risk in patients prior to obtaining diagnostics.
    • The Center for Medicare and Medicaid Services (CMS) has added a sepsis quality measure (SEP-1) as a reporting requirement for all US hospital tied to Medicare & Medicaid reimbursement. This measure has increased awareness of sepsis performance and focused quality efforts on improvement.
    • There have been new studies investigating the effect of time-to-antibiotics on mortality with focus on elements of the 3 h and 6 h sepsis treatment bundles. A large retrospective study in New York state showed that timely delivery of the 3-hour bundle (lactate measurement, blood cultures, antibiotics) lead to improved outcomes, whereas timely delivery of the 6-hour bundle (30 mL/kg fluid bolus, timely vasopressor therapy) did not.
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