- Antihistamines to block the binding of histamine at target sites, aspirin and NSAIDs to block the synthesis of prostaglandin D2, and leukotriene antagonists blocking it’s downstream effects
- Allergen immunotherapy to induce long-lasting clinical tolerance in sensitized patients in an antigen-specific approach
- Monoclonal antibodies against IL-5 (mepolizumab, reslizumab), and IL-5 receptor (benralizumab) for treatment of hypereosinphilia and proposed for allergy diseases
Latest Updates
- An unstable patient with wide-complex tachycardia may be approached with the usual advanced cardiac life support algorithms: high-quality chest compressions and defibrillation in pulseless patients and synchronized cardioversion in patients with a pulse.
- Recent data suggest limited utility of Advanced Cardiac Life Support interventions (medications, advanced airway) compared with basic life support, reminding providers to focus on effective cardiopulmonary resuscitation and defibrillation (avoiding implantable cardioverter-defibrillator or pacemaker devices).
- Polidocanol is now FDA approved in a foam formulation
- Correction of axial great spahenous vein reflux first is essential for optimal success of venous sclerotherapy treatments
- Venous duplex ultrasonography has revolutionized the treatment of varicose and spider veins.
- Sclerotherapy is reproducible and noninvasive and can objectively identify areas of reflux in the great and small saphenous systems, as well as detect pathologic conditions in the deep venous system and incompetent perforating vessels. Sclerosants may be classified into three main categories: hypertonic solutions, chemical irritants, and detergents.
- The detergent class of sclerosants form aggregates on endothelial cell surfaces and cause endofibrosis by disrupting the integrity of the cells. Polidocanol (POL) is the most commonly used sclerotherapy agent worldwide. Sodium tetradecyl sulfate (STS) is also a commonly used agent in the United States; both POL and STS are approved by the FDA.
- Antihistamines to block the binding of histamine at target sites, aspirin and NSAIDs to block the synthesis of prostaglandin D2, and leukotriene antagonists blocking it’s downstream effects
- Allergen immunotherapy to induce long-lasting clinical tolerance in sensitized patients in an antigen-specific approach
- Monoclonal antibodies against IL-5 (mepolizumab, reslizumab), and IL-5 receptor (benralizumab) for treatment of hypereosinphilia and proposed for allergy diseases
- Latest ECC guidelines for management of infective endocarditis
- Latest IDSA guidelines on diagnosis and management of prosthetic joint infection
- Latest scientific statement from AHA on infective endocarditis in adults
- Latest IDSA for Healthcare Epidemiology of America guidelines on antibiotic stewardship programs
- Latest ECC guidelines for management of infective endocarditis
- Latest IDSA guidelines on diagnosis and management of prosthetic joint infection
- Latest scientific statement from AHA on infective endocarditis in adults
- Latest IDSA for Healthcare Epidemiology of America guidelines on antibiotic stewardship programs
- Latest ECC guidelines for management of infective endocarditis
- Latest IDSA guidelines on diagnosis and management of prosthetic joint infection
- Latest scientific statement from AHA on infective endocarditis in adults
- Latest IDSA for Healthcare Epidemiology of America guidelines on antibiotic stewardship programs
Pharmacologic Differences in Children
- There is increasing focus on the impact of anesthetic medication effects on the developing brain with a goal to improve patient safety.
- Dexmedetomidine is one particular medication found to confer protection to the developing brain in the anesthesia setting and will likely have increasing clinical applications for the pediatric anesthesiologist.
- Technology and innovative engineering have led to the development and application of tools to improve pediatric patient compliance with anesthesia-related procedures such as needleless medication delivery systems to aid in painless IV placement and the use of small electronics as distraction for mask induction.
