Latest Updates

Regional Therapies for Extremity Sarcoma

Chiara Colombo, MD, Sandro Pasquali, MD
    • Identification of effective treatment strategies
    • Improvements in patient risk stratification
    • Neoadjuvant epirubicin and ifosfamide in a randomized clinical trial has shown to be effective in improving survival of patients affected by five high-risk soft tissue sarcoma histologies (undifferentiated pleomorphic sarcoma, myxoid liposarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, and leiomyosarcoma) of the trunk and extremities
    • Inclusion of prognostic models in the eighth edition of the AJCC TNM staging system

Regional Therapies for Extremity Sarcoma

Chiara Colombo, MD, Sandro Pasquali, MD
    • Identification of effective treatment strategies
    • Improvements in patient risk stratification
    • Neoadjuvant epirubicin and ifosfamide in a randomized clinical trial has shown to be effective in improving survival of patients affected by five high-risk soft tissue sarcoma histologies (undifferentiated pleomorphic sarcoma, myxoid liposarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, and leiomyosarcoma) of the trunk and extremities
    • Inclusion of prognostic models in the eighth edition of the AJCC TNM staging system

Adherence to Posttransplantation Medical Regimen

Lauren S Jones, BS, Marina Serper, MD, MS
    • Medication nonadherence is common post-liver transplantation.
    • Nonadherence is associated with graft failure and posttransplantation hospitalizations.
    • Risk factors for nonadherence include low social support, younger age, poor medication understanding, and depression.
    • Validated measures to assess adherence include as self-report questionnaires, electronic monitoring devices, and immunosuppression levels.

HER-2-Amplified Breast Cancer

Zahraa Al-Hilli, MD, Judy C Boughey, MD
    • The monoclonal antibody trastuzumab has revolutionized the treatment of HER-2-positive breast cancer, resulting in improved patient outcomes.
    • Dual anti-HER-2 therapy has been shown to result in increased pathologic complete response (pCR) rates in patients treated in the neoadjuvant setting.
    • pCR has been shown to be associated with a good prognosis and outcome in patients receiving neoadjuvant chemotherapy.
    • Novel anti-HER-2 agents are currently being investigated in ongoing trials.

Management of Acute Iliofemoral Deep Vein Thrombosis

Albeir Y Mousa, MD, FACS, RPVI, MPH, MBA
    • Mechanical removal of acute venous thrombus with increased safety
    • Selection of catheter-directed thrombolysis in patients with thrombotic iliofemoral DVT
    • Protocols of pharmacomechanical thrombolysis
    • Using intravascular ultrasonography to guide intraoperative therapy

HER-2-Amplified Breast Cancer

Zahraa Al-Hilli, MD, Judy C Boughey, MD
    • The monoclonal antibody trastuzumab has revolutionized the treatment of HER-2-positive breast cancer, resulting in improved patient outcomes.
    • Dual anti-HER-2 therapy has been shown to result in increased pathologic complete response (pCR) rates in patients treated in the neoadjuvant setting.
    • pCR has been shown to be associated with a good prognosis and outcome in patients receiving neoadjuvant chemotherapy.
    • Novel anti-HER-2 agents are currently being investigated in ongoing trials.

Management of Acute Iliofemoral Deep Vein Thrombosis

Albeir Y Mousa, MD, FACS, RPVI, MPH, MBA
    • Mechanical removal of acute venous thrombus with increased safety
    • Selection of catheter-directed thrombolysis in patients with thrombotic iliofemoral DVT
    • Protocols of pharmacomechanical thrombolysis
    • Using intravascular ultrasonography to guide intraoperative therapy

Hand Infections

Scott D Lifchez, MD, FACS, Colton McNichols, MD
    • A recently published large database study of outpatient hand surgery procedures states that postoperative infection risk is less than 1%.
    • Prophylactic antibiotics for elective procedures lasting less than 2 hours are not necessary.
    • Trimethoprim/sulfamethoxazole and doxycycline are commonly used PO empiric antibiotics for hand infections due to the increased prevalence of methicillin-resistant Staphylococcus aureus.
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