- Screening strategies have improved survival, but the effect has plateaued recently. 1
- Oxaliplatin-based adjuvant chemotherapy has extended survival for patients with advanced disease. 2
- The COST trial validated laparoscopic colon resection, while data is emerging regarding the robotic approach. 3,4
- Recent investigations into molecular markers may offer new opportunities for disease detection, prognosis, and treatment. 5-7
Latest Updates
Management of Metastatic Castrate-sensitive Prostate Cancer
- Luteinizing hormone–releasing hormone agonists are the current standard of care in androgen deprivation therapy (ADT) for metastatic prostate cancer (mPCa).
- Men with hormone-naive mPCa should be offered six cycles of docetaxel in addition to ADT.
- Abiraterone acetate, in addition to ADT, represents a valid alternative to docetaxel and ADT in men with hormone-naive mPCa.
- Discovery of germline RET oncogene mutations leading to MEN2 syndromes and familial medullary thyroid cancer
- Genotype-phenotype correlations for RET mutations allowed targeted screening and intervention in carriers.
- Development of RET-targeted kinase inhibitors (and multikinase inhibitors) as targeted therapies for patients with metastatic and progressive medullary thyroid cancer
Stereotactic Body Radiation and Other Ablative Therapies
- Classification of medically inoperable patients with nonsmall cell lung cancer
- Stereotactic body radiotherapy in nonsmall cell lung cancer
- Ablative therapy in nonsmall cell lung cancer
- Bronchoscopic ablation for nonsmall cell lung cancer
- Discovery of germline RET oncogene mutations leading to MEN2 syndromes and familial medullary thyroid cancer
- Genotype-phenotype correlations for RET mutations allowed targeted screening and intervention in carriers.
- Development of RET-targeted kinase inhibitors (and multikinase inhibitors) as targeted therapies for patients with metastatic and progressive medullary thyroid cancer
- Randomized trials of treatments (tamoxifen plus radiation versus tamoxifen alone) showed no difference in survival rates.
- Randomized trials of quadrantectomy with axillary lymph node dissection versus quadrantectomy alone showed that overall survival, distant metastases, and breast cancer mortality were no different.
Biomechanics of the Diabetic Foot
- Identifying unique and important aspects foot and ankle anatomy that are pivotal to normal and abnormal ambulation.
- Forces involved in the biomechanics of the diabetic foot and ankle which lead to ulcer development and chronicity.
- Options that include conservative and surgical offloading approaches to prevent and treat diabetic foot ulcers.
Child Abuse and Nonaccidental Trauma
- Abusive injuries account for over 1% of pediatric emergency department visits.
- Skeletal survey should now be obtained in any child under age 3 with concern for abusive injury.
- Cardiopulmonary resuscitation does not lead to significant rib fractures or retinal hemorrhages, and these conditions should be considered highly concerning for abusive injury.
