Latest Updates

Liposarcoma

Joseph G Crompton, MD, PhD, Sarah M Dry, MD, Fritz C Eilber, MD, Arun S Singh, MD
    • Limb-sparing surgery with radiation for extremity soft tissue sarcoma is not inferior to amputation in outcome of disease-specific mortality.
    • Completeness of resection (R0, R1, R2) of retroperitoneal soft tissue sarcoma correlates with patient survival.
    • Emerging molecular characterization of subtypes of liposarcoma has provided novel therapeutic targets, such as CDK4 inhibitors.

Headache

Benjamin W Friedman, MD, MS
    • Targeting calcitonin gene related peptide can improve migraine pain
    • Greater occipital nerve blocks may alleviate migraine acutely
    • Clinical decision rules can be used to exclude subarachnoid hemorrhage

Coma and Disorders of Consciousness

Nicole M Dubosh, MD, Jonathan A. Edlow, MD, FACEP
    • Non-convulsive status epilepticus is an important cause of coma that requires EEG for diagnosis.
    • Basilar artery stroke is a treatable cause of altered mentation
    • Physicians should actively seek to identify treatable structural or metabolic causes of coma

Coma and Disorders of Consciousness

Nicole M Dubosh, MD, Jonathan A. Edlow, MD, FACEP
    • Non-convulsive status epilepticus is an important cause of coma that requires EEG for diagnosis.
    • Basilar artery stroke is a treatable cause of altered mentation
    • Physicians should actively seek to identify treatable structural or metabolic causes of coma

Benign Tumors of the Spleen

Brandon Chapman, MD, Alessandro Paniccia, MD
    • Laparoscopic approach to splenectomy
    • Frequent incidental finding with increased use of imaging

Benign Tumors of the Spleen

Brandon Chapman, MD, Alessandro Paniccia, MD
    • Laparoscopic approach to splenectomy
    • Frequent incidental finding with increased use of imaging

Failure to Thrive in Infants and Toddlers

Madhura Y Phadke, MD, Anthony F Porto, MD, MPH
    • WHO growth charts are recommended for children 0 to 2 years, and CDC growth charts are recommended for children 2 to 18 years of age.
    • Blenderized diets may be more wholesome than traditional formula diets for children requiring enteral tube feeding. 
    • It is important to evaluate whether patients have a true allergy and need to avoid cow’s milk as milk alternatives may contain fewer calories and less protein.

Colon Cancer

Richard S Hoehn, MD, Felipe Quezada-Diaz, MD, Jesse J Smith, MD, PhD
    • Screening strategies have improved survival, but the effect has plateaued recently. 1
    • Oxaliplatin-based adjuvant chemotherapy has extended survival for patients with advanced disease. 2
    • The COST trial validated laparoscopic colon resection, while data is emerging regarding the robotic approach. 3,4
    • Recent investigations into molecular markers may offer new opportunities for disease detection, prognosis, and treatment. 5-7
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