What's New | Decker

Alexander Lazar, MD, PhD, Ian E McCutcheon, Keila E Torres, MD, PhD, Wei-Lien Wang, MD

Oncogenic signatures responsible for the transformation MPNST include activation of the STAT3/HIF, catenin/Wnt and RHO/ROCK pathways.
MPNSTs often harbor recurrent inactivation of polycomb repressive complex 2 from somatic mutation of EED and/or SUZ12.
Genetic analysis revealed germline mutations in SMARCB1 in approximately 50% of individuals affected by familial schwannomatosis.
Germline mutations in LZTR1 were identified in about 80% of schwannomatosis cases lacking mutations in SMARCB1.

2018 AAFP Key Recommendations for Heel Pain
2017 AAFP Practice Guidelines – Low Back Pain: Noninvasive Management
2015 AAFP Key Recommendations for Corticosteroid Injections – Common Musculoskeletal Conditions

Thurston M. Bauer, MD, Mark A. Farber, MD

BTAI is now the gold standard n treating patients with these problems
The grade of injury with these lesions has been defined and there is controversy on which lesion should be treated and how emergently
Recently in the US a device changed its IFU because of complications after TEVAR for BTAI. It was being used outside its IFU.
Recent advancement on sizing and device differences between BTAI and other pathologies treated with TEVAR

Lindy L. Davis, MD, Emmanuel M. Gabriel, MD, PhD, Joseph J. Skitzki, MD

Aslam Ejaz, MD, MPH, Bradley N Reames, MD, MS, Matthew J Weiss, MD

Thurston M. Bauer, MD, Mark A. Farber, MD

BTAI is now the gold standard n treating patients with these problems
The grade of injury with these lesions has been defined and there is controversy on which lesion should be treated and how emergently
Recently in the US a device changed its IFU because of complications after TEVAR for BTAI. It was being used outside its IFU.
Recent advancement on sizing and device differences between BTAI and other pathologies treated with TEVAR

Allison Dalton, MD

Pulmonary hypertension can be treated with single or combination therapy employing calcium channel blockers, phosphodiesterase inhibitors, guanylate cyclase stimulators, endothelin receptor antagonists, and prostanoids.
Levosimendan is a calcium sensitizer used to treat cardiogenic shock and right heart failure.
Clevidipine is an ultra-rapid acting calcium channel blocker used for perioperative hypertension management in cardiovascular and vascular diseases, neurosurgery, and surgery for pheochromocytoma.

Nirav K Desai, Samir Softic

2017 Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practive Guideline
2017 NASPGHAN clinical practice guideline for the diagnosis and treatment of nonalcoholic fatty liver disease in children: recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)

Soft Tissue Cancer